Endocrinology and Metabolism

Original Articles

Thyroid
The Diagnostic Role of Repeated Biopsy of Thyroid Nodules with Atypia of Undetermined Significance with Architectural Atypia on Core-Needle Biopsy: Hye Hyeon Moon, Sae Rom Chung, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee, Jung Hwan Baek; Endocrinol Metab. 2024;39(2):300-309. Published online January 3, 2024; DOI: https://doi.org/10.3803/EnM.2023.1818

471 View
31 Download

Abstract PDF Supplementary Material PubReader ePub: Background
We aimed to evaluate the utility of repeat biopsy of thyroid nodules classified as atypia of undetermined significance with architectural atypia (IIIB) on core-needle biopsy (CNB).
Methods
This retrospective study evaluated patients with thyroid nodules categorized as IIIB on CNB between 2013 and 2015. Demographic characteristics, subsequent biopsy results, and ultrasound (US) images were evaluated. The malignancy rates of nodules according to number of CNBs and the number of IIIB diagnoses was compared. Demographic and US features were evaluated to determine factors predictive of malignancy.
Results
Of 1,003 IIIB nodules on CNB, the final diagnosis was determined for 328 (32.7%) nodules, with 121 of them confirmed as malignant, resulting in a malignancy rate of 36.9% (95% confidence interval, 31.7% to 42.1%). Repeat CNB was performed in 248 nodules (24.7%), with 75 (30.2%), 131 (52.8%), 13 (5.2%), 26 (10.5%), one (0.4%), and two (0.8%) reclassified into categories II, IIIB, IIIA, IV, V, and VI, respectively. Malignancy rates were not significantly affected by the number of CNBs (P=0.291) or the number of IIIB diagnoses (P=0.473). None of the nodules confirmed as category II on repeat CNB was malignant. US features significantly associated with malignancy (P<0.003) included solid composition, irregular margins, microcalcifications, and high suspicion on the US risk stratification system.
Conclusion
Repeat biopsy of nodules diagnosed with IIIB on CNB did not increase the detection of malignancy but can potentially reduce unnecessary surgery. Repeat biopsy should be performed selectively, with US features guiding the choice between repeat biopsy and diagnostic surgery.

Thyroid
Immunoglobulin G4-Related Thyroid Disease: A Single-Center Experience and Literature Review: Meihua Jin, Bictdeun Kim, Ahreum Jang, Min Ji Jeon, Young Jun Choi, Yu-Mi Lee, Dong Eun Song, Won Gu Kim; Endocrinol Metab. 2022;37(2):312-322. Published online April 25, 2022; DOI: https://doi.org/10.3803/EnM.2021.1318

4,033 View
180 Download
2 Web of Science
2 Crossref

Background
Immunoglobulin G4 (IgG4)-related disease is an entity that can involve the thyroid gland. The spectrum of IgG4-related thyroid disease (IgG4-RTD) includes Hashimoto thyroiditis (HT) and its fibrotic variant, Riedel thyroiditis, as well as Graves’ disease. The early diagnosis of IgG4-RTD is important because it is a medically treatable disease, and a delay in the diagnosis might result in unnecessary surgery. We present a case series of IgG4-RTD with a review of the literature.
Methods
We retrospectively reviewed the clinical presentation and the radiological and pathological findings of patients diagnosed with IgG4-RTD between 2017 and 2021 at a tertiary medical center in Korea. We also conducted a literature review of IgG4-RTD.
Results
Five patients were diagnosed with IgG4-RTD during the study period. The patients’ age ranged from 31 to 76 years, and three patients were men. Most patients visited the clinic for a neck mass, and hypoechogenic nodular lesions were observed on neck ultrasonography. Three patients had IgG4 HT, and two patients had IgG4 Riedel thyroiditis. All patients developed hypothyroidism that necessitated L-thyroxine replacement. The diagnosis of IgG4-RTD was confirmed after a pathological examination of the surgical specimen in the first two cases. However, the early diagnosis was possible after a core needle biopsy in three clinically suspected patients.
Conclusion
The diagnosis of IgG4-RTD requires clinical suspicion combined with serology and histological analyses using IgG4 immunostaining. The early diagnosis of IgG4-RTD is difficult; thus, biopsy with IgG4 immunostaining and serum IgG4 measurements will help diagnose patients suspected of having IgG4-RTD.

Citations

Citations to this article as recorded by

Are sonographic characteristics of Hashimoto’s thyroiditis related with immunologic parameters? A cross-sectional study
K. Kenarlı, A. B. Bahçecioğlu, Ö. B. Aksu, S. Güllü
Journal of Endocrinological Investigation.2024;[Epub] CrossRef
Reshaping the Concept of Riedel’s Thyroiditis into the Larger Frame of IgG4-Related Disease (Spectrum of IgG4-Related Thyroid Disease)
Mara Carsote, Claudiu Nistor
Biomedicines.2023; 11(6): 1691. CrossRef

Clinical Study
Effectiveness of Injecting Cold 5% Dextrose into Patients with Nerve Damage Symptoms during Thyroid Radiofrequency Ablation: Min Kyoung Lee, Jung Hwan Baek, Sae Rom Chung, Young Jun Choi, Yu-Mi Lee, Tae Yong Kim, Jeong Hyun Lee; Endocrinol Metab. 2020;35(2):407-415. Published online June 24, 2020; DOI: https://doi.org/10.3803/EnM.2020.35.2.407

6,097 View
140 Download
12 Web of Science
14 Crossref

Abstract PDF PubReader ePub

Background
Although radiofrequency ablation (RFA) is a safe treatment for thyroid tumors, nerve damage is a frequent complication. A previous retrospective study suggested that an injection of cold 5% dextrose in water (5% DW) can reduce nerve damage during RFA. This study validated the efficacy of injecting cold 5% DW for management of nerve damage during RFA.
Methods
Between November 2017 and December 2018, 242 patients underwent 291 RFA sessions for treatment of benign thyroid nodules or recurrent thyroid cancers. Using a standardized technique, cold (0°C to 4°C) 5% DW was immediately injected around the damaged nerve into patients with any symptoms suggesting nerve damage. The incidence of nerve damage, the volume of 5% DW injected, symptom recovery time and the incidence of permanent nerve damage were evaluated.
Results
Nineteen patients experienced nerve damage symptoms related to 21 RFA sessions, including 17 patients during 19 sessions and two patients on the day after two sessions. Patients with nerve damage symptoms detected during RFA were treated by injection of a mean 41 mL (range, 3 to 260) cold 5% DW, but the two patients who experienced symptoms the next day did not receive cold 5% DW injections. Immediate recovery was observed after 15 RFA sessions in 14 patients. No patient experienced permanent nerve damage.
Conclusion
Injection of cold 5% DW is effective in managing nerve damage during RFA of thyroid lesions.

Citations

Citations to this article as recorded by

The Role of Radiofrequency Ablation in Benign and Malignant Thyroid Nodules
Meghal Shah, Catherine McManus
Surgical Clinics of North America.2024;[Epub] CrossRef
Clinical and Economic Evaluation of Ultrasound-Guided Radiofrequency Ablation vs. Parathyroidectomy for Patients with Primary Hyperparathyroidism: A Cohort Study
Hui-hui Chai, Zhan-jing Dai, Bai Xu, Qiao-hong Hu, Hong-feng He, Ying Xin, Wen-wen Yue, Cheng-zhong Peng
Academic Radiology.2023; 30(11): 2647. CrossRef
Efficacy of single-session radiofrequency ablation (RFA) in rendering euthyroidism for persistent/relapsed Graves’ disease, a pilot study
Man Him Matrix Fung, Brian Hung Hin Lang
European Radiology.2023; 33(9): 6534. CrossRef
Radiofrequency Ablation of Cervical Thyroid Cancer Metastases—Experience of Endocrinology Practices in the United States
Shahzad Ahmad, Jules Aljammal, Ian Orozco, Sheharyar Raashid, Fizza Zulfiqar, Sean P Nikravan, Iram Hussain
Journal of the Endocrine Society.2023;[Epub] CrossRef
Radiofrequency ablation of benign thyroid nodules: the value of anterolateral hydrodissection
So Yeong Jeong, Jung Hwan Baek, Sae Rom Chung, Young Jun Choi, Ki-Wook Chung, Tae Yong Kim, Jeong Hyun Lee
Ultrasonography.2023; 42(3): 432. CrossRef
Effective and Safe Application of Radiofrequency Ablation for Benign Thyroid Nodules
Jin Yong Sung
Journal of the Korean Society of Radiology.2023; 84(5): 985. CrossRef
Assessment of thyroid-specific quality of life in patients with benign symptomatic thyroid nodules treated with radiofrequency or ethanol ablation: a prospective multicenter study
So Yeong Jeong, Eun Ju Ha, Jung Hwan Baek, Tae Yong Kim, Yu-Mi Lee, Jeong Hyun Lee, Jeonghun Lee
Ultrasonography.2022; 41(1): 204. CrossRef
Management of Recurrent Laryngeal Nerve Injury During Radiofrequency Ablation of Thyroid Nodules
Jules Aljammal, Iram Hussain, Shahzad Ahmad
AACE Clinical Case Reports.2022; 8(2): 102. CrossRef
Thermal Ablation for the Management of Papillary Thyroid Microcarcinoma in the Era of Active Surveillance and Hemithyroidectomy
Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Jeong Hyun Lee
Current Oncology Reports.2022; 24(8): 1045. CrossRef
Improving Voice Outcomes after Thyroid Surgery and Ultrasound-Guided Ablation Procedures
Pia Pace-Asciak, Jon O. Russell, Ralph P. Tufano
Frontiers in Surgery.2022;[Epub] CrossRef
Using Intra‐Operative Laryngeal Ultrasonography as a Real‐Time Tool in Assessing Vocal Cord Function During Radiofrequency Ablation of the Thyroid Gland
Matrix Man Him Fung, Brian Hung Hin Lang
World Journal of Surgery.2022; 46(9): 2206. CrossRef
Long-term outcome of microwave ablation for benign thyroid nodules: Over 48-month follow-up study
Jia-Rui Du, Wen-Hui Li, Cheng-Hai Quan, Hui Wang, Deng-Ke Teng
Frontiers in Endocrinology.2022;[Epub] CrossRef
Continuous neuromonitoring during radiofrequency ablation of benign thyroid nodules provides objective evidence of laryngeal nerve safety
Catherine F. Sinclair, Maria J. Téllez, Roberto Peláez-Cruz, Alba Díaz-Baamonde, Sedat Ulkatan
The American Journal of Surgery.2021; 222(2): 354. CrossRef
Future Considerations and Directions for Thermal Ablative Technologies
Jonathon Russell, Catherine F. Sinclair
Current Otorhinolaryngology Reports.2021; 9(2): 210. CrossRef

Clinical Study
Long-Term Results of Thermal Ablation of Benign Thyroid Nodules: A Systematic Review and Meta-Analysis: Se Jin Cho, Jung Hwan Baek, Sae Rom Chung, Young Jun Choi, Jeong Hyun Lee; Endocrinol Metab. 2020;35(2):339-350. Published online June 24, 2020; DOI: https://doi.org/10.3803/EnM.2020.35.2.339

10,872 View
306 Download
39 Web of Science
45 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Ultrasound-guided thermal ablations have become one of the main options for treating benign thyroid nodules. To determine efficacy of thermal ablation of benign thyroid nodules, we performed a meta-analysis of studies with long-term follow-up of more than 3 years.
Methods
Databases were searched for studies published up to August 25, 2019, reporting patients with benign thyroid nodules treated with thermal ablation and with follow-up data of more than 3 years. Data extraction and quality assessment were performed according to PRISMA guidelines. The analysis yielded serial volume reduction rates (VRRs) of ablated nodules for up to 3 years or more, and adverse effect of ablation during follow-up. Radiofrequency ablation (RFA) and laser ablation (LA) were compared in a subgroup analysis.
Results
The pooled VRRs for ablated nodules showed rapid volume reduction before 12 months, a plateau from 12 to 36 months, and more volume reduction appearing after 36 months, demonstrating long-term maintenance of treatment efficacy. Thermal ablation had an acceptable complication rate of 3.8%. Moreover, patients undergoing nodule ablation showed no unexpected delayed complications during the follow-up period. In the subgroup analysis, RFA was shown to be superior to LA in terms of the pooled VRR and the number of patients who underwent delayed surgery.
Conclusion
Thermal ablations are safe and effective methods for treating benign thyroid nodules, as shown by a long follow-up analysis of more than 3 years. In addition, RFA showed superior VRRs compared with LA for the treatment of benign thyroid nodules, with less regrowth and less delayed surgery.

Citations

Citations to this article as recorded by

Five-year follow-up results of thermal ablation for benign thyroid nodules: Systematic review and meta-analysis
Xidong Xu, Ying Peng, Guoxin Han
American Journal of Otolaryngology.2024; 45(1): 104025. CrossRef
Radiofrequency Ablation for Benign Nodules and for Cancer, Too?
Jonathon O. Russell, Kaitlyn M. Frazier
Otolaryngologic Clinics of North America.2024; 57(1): 83. CrossRef
An anthropomorphic thyroid phantom for ultrasound‐guided radiofrequency ablation of nodules
Tim Boers, Wyger Brink, Leonardo Bianchi, Paola Saccomandi, Johan van Hespen, Germen Wennemars, Sicco Braak, Michel Versluis, Srirang Manohar
Medical Physics.2024; 51(2): 826. CrossRef
The safety and efficacy of radiofrequency ablation in benign pediatric thyroid disease in the US: An initial case series
Grace S. Kim, Hilary Seeley, Julia Noel, Iram Ahmad, Kara Meister
Laryngoscope Investigative Otolaryngology.2024;[Epub] CrossRef
Radioiodine versus radiofrequency ablation to treat autonomously functioning thyroid nodules: a systematic review and comparative meta-analysis
Luca Giovanella, Maria Luisa Garo, Alfredo Campenní, Petra Petranović Ovčariček
European Journal of Nuclear Medicine and Molecular Imaging.2024;[Epub] CrossRef
Novel and Advanced Ultrasound Techniques for Thyroid Thermal Ablation
Wai-Kin Chan, Jui-Hung Sun, Miaw-Jene Liou, Chia-Jung Hsu, Yu-Ling Lu, Wei-Yu Chou, Yan-Rong Li, Feng-Hsuan Liu
Endocrinology and Metabolism.2024; 39(1): 40. CrossRef
Sublethal thermal stress promotes migration and invasion of thyroid cancer cells
Chi-Yu Kuo, Chung-Hsin Tsai, Jun Kui Wu, Shih-Ping Cheng, Yi-Hsien Hsieh
PLOS ONE.2024; 19(2): e0298903. CrossRef
The Role of Radiofrequency Ablation in Benign and Malignant Thyroid Nodules
Meghal Shah, Catherine McManus
Surgical Clinics of North America.2024;[Epub] CrossRef
Comparison of ultrasound-guided microwave ablation, laser ablation, and radiofrequency ablation for the treatment of elderly patients with benign thyroid nodules: A meta-analysis
Ying Qian, Zheng Li, Chunyun Fan, Yong Huang
Experimental Gerontology.2024; 191: 112425. CrossRef
Ultrasound imaging in thyroid nodule diagnosis, therapy, and follow‐up: Current status and future trends
Tim Boers, Sicco J. Braak, Nicole E. T. Rikken, Michel Versluis, Srirang Manohar
Journal of Clinical Ultrasound.2023; 51(6): 1087. CrossRef
Ultrasound (US)-Guided Ablation of Thyroid Nodules
Byung Seup Kim
Journal of Surgical Ultrasound.2023; 10(1): 14. CrossRef
Ultrasound-Guided Radiofrequency Ablation versus Thyroidectomy for the Treatment of Benign Thyroid Nodules in Elderly Patients: A Propensity-Matched Cohort Study
L. Yan, X.Y. Li, Y. Li, Y. Luo
American Journal of Neuroradiology.2023; 44(6): 693. CrossRef
Minimally Invasive Ablative Treatments for Benign Thyroid Nodules: Current Evidence and Future Directions
Enrico Papini, Laszlo Hegedüs
Thyroid®.2023; 33(8): 890. CrossRef
Influence factors and nomogram for volume reduction rate in benign thyroid nodule after thermal ablation
Shiliang Cao, Lijia Wang, Ying Wei, Zhenlong Zhao, Jie Wu, Mingan Yu
International Journal of Hyperthermia.2023;[Epub] CrossRef
Choice in Ablative Therapies for Thyroid Nodules
Q Lina Hu, Jennifer H Kuo
Journal of the Endocrine Society.2023;[Epub] CrossRef
2022 Taiwan clinical multicenter expert consensus and recommendations for thyroid radiofrequency ablation
Wei-Che Lin, Wen-Chieh Chen, Pei-Wen Wang, Yi-Chia Chan, Yen-Hsiang Chang, Harn-Shen Chen, Szu-Tah Chen, Wei-Chih Chen, Kai-Lun Cheng, Shun-Yu Chi, Pi-Ling Chiang, Chen-Kai Chou, Feng-Fu Chou, Shun-Chen Huang, Feng-Hsuan Liu, Sheng-Dean Luo, Fen-Yu Tseng,
Ultrasonography.2023; 42(3): 357. CrossRef
Comparison of the Efficiency of Radiofrequency and Microwave Ablation Methods in the Treatment of Benign Thyroid Nodules
Mahi N. Cerit, Cem Yücel, Ethem T. Cerit, Mehmet M. Yalçın, Halit N. Şendur, Suna Ö. Oktar
Academic Radiology.2023; 30(10): 2172. CrossRef
Radiofrequency ablation for autonomously functioning nodules as treatment for hyperthyroidism: subgroup analysis of toxic adenoma and multinodular goitre and predictors for treatment success
M. M. D. van der Meeren, F. B. M. Joosten, S. H. P. P. Roerink, L. N. Deden, W. J. G. Oyen
European Journal of Nuclear Medicine and Molecular Imaging.2023; 50(12): 3675. CrossRef
Massive Hemorrhage and Mortality Following Thyroid Radiofrequency Ablation
Seulki Song, Jin Pyeong Kim
Ear, Nose & Throat Journal.2023;[Epub] CrossRef
Clinical Approach for Thyroid Radiofrequency Ablation
Jung Suk Sim
Journal of the Korean Society of Radiology.2023; 84(5): 1017. CrossRef
General Principles for the Safe Performance, Training, and Adoption of Ablation Techniques for Benign Thyroid Nodules: An American Thyroid Association Statement
Catherine F. Sinclair, Jung Hwan Baek, Kathleen E. Hands, Steven P. Hodak, Timothy C. Huber, Iram Hussain, Brian Hung-Hin Lang, Julia E. Noel, Maria Papaleontiou, Kepal N. Patel, Gilles Russ, Jonathon Russell, Stefano Spiezia, Jennifer H. Kuo
Thyroid®.2023; 33(10): 1150. CrossRef
A comprehensive review of interventional ablation techniques for the management of thyroid nodules and metastatic lymph nodes
Jennifer H. Kuo, Catherine F. Sinclair, Brian Lang, Stefano Spiezia, Mingan Yu, Eun Ju Ha, Dong Gyu Na, Chiara Offi, Kepal N. Patel, Jung Hwan Baek
Surgery.2022; 171(4): 920. CrossRef
Radiofrequency ablation and related ultrasound‐guided ablation technologies for treatment of benign and malignant thyroid disease: An international multidisciplinary consensus statement of the American Head and Neck Society Endocrine Surgery Section with
Lisa A. Orloff, Julia E. Noel, Brendan C. Stack, Marika D. Russell, Peter Angelos, Jung Hwan Baek, Kevin T. Brumund, Feng‐Yu Chiang, Mary Beth Cunnane, Louise Davies, Andrea Frasoldati, Anne Y. Feng, Laszlo Hegedüs, Ayaka J. Iwata, Emad Kandil, Jennifer K
Head & Neck.2022; 44(3): 633. CrossRef
Assessment of thyroid-specific quality of life in patients with benign symptomatic thyroid nodules treated with radiofrequency or ethanol ablation: a prospective multicenter study
So Yeong Jeong, Eun Ju Ha, Jung Hwan Baek, Tae Yong Kim, Yu-Mi Lee, Jeong Hyun Lee, Jeonghun Lee
Ultrasonography.2022; 41(1): 204. CrossRef
Thyroid Nodule Radiofrequency Ablation: Complications and Clinical Follow Up
James Y. Lim, Jennifer H. Kuo
Techniques in Vascular and Interventional Radiology.2022; 25(2): 100824. CrossRef
Radiofrequency Ablation of Solid, Non-Functional Thyroid Nodules
Michael Douek
Techniques in Vascular and Interventional Radiology.2022; 25(2): 100821. CrossRef
Efficacy and Safety of Thermal Ablation for Treating Lymph Node Metastasis From Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis
Zheng Ding, Juan Chen, Zhiguang Chen, Xiaoke Zeng, Pengchao Zheng, Xuemei Wang, Xinwu Cui, Liang Sang
Frontiers in Oncology.2022;[Epub] CrossRef
Intraoperative Neuromonitoring: Evaluating the Role of Continuous IONM and IONM Techniques for Emerging Surgical and Percutaneous Procedures
Catherine McManus, Jennifer Hong Kuo
Frontiers in Endocrinology.2022;[Epub] CrossRef
Thermal Ablation for the Management of Papillary Thyroid Microcarcinoma in the Era of Active Surveillance and Hemithyroidectomy
Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Jeong Hyun Lee
Current Oncology Reports.2022; 24(8): 1045. CrossRef
enhanced anarchic society optimization technique for the classification of ultrasound thyroid images using ILBP
D. Anitha, S. Sathya Priya
International journal of health sciences.2022; : 4713. CrossRef
Image-Guided Percutaneous Ablation for Primary and Metastatic Tumors
Arian Mansur, Tushar Garg, Apurva Shrigiriwar, Vahid Etezadi, Christos Georgiades, Peiman Habibollahi, Timothy C. Huber, Juan C. Camacho, Sherif G. Nour, Alan Alper Sag, John David Prologo, Nariman Nezami
Diagnostics.2022; 12(6): 1300. CrossRef
Efficacy and safety of ultrasound-guided microwave ablation versus surgical resection for Bethesda category IV thyroid nodules: A retrospective comparative study
Jingjing Yang, Ya Zhang, Xingjia Li, Yueting Zhao, Xue Han, Guofang Chen, Xiaoqiu Chu, Ruiping Li, Jianhua Wang, Fei Huang, Chao Liu, Shuhang Xu
Frontiers in Endocrinology.2022;[Epub] CrossRef
Long-term follow-up of the radiofrequency ablation of benign thyroid nodules: the value of additional treatment
Hyun Jin Kim, Jung Hwan Baek, Woojin Cho, Jung Suk Sim
Ultrasonography.2022; 41(4): 661. CrossRef
Das „heiße“ Schilddrüsenkarzinom mit einem kritischen Blick auf die Thermoablation
Joachim Jähne, Andreas Niesen, Joachim Bernhardts, Marija Hillemans
Der Chirurg.2021; 92(1): 34. CrossRef
Current Practice of Percutaneous Ablation Technologies for Thyroid Nodules 2020
Haris Muhammad, Jonathon O. Russell, Prasanna Santhanam, Aniqa Tehreem, Ralph P. Tufano
Current Otorhinolaryngology Reports.2021; 9(1): 52. CrossRef
RFA and benign thyroid nodules: Review of the current literature
Haris Muhammad, Prasanna Santhanam, Jonathon O. Russell, Jennifer H. Kuo
Laryngoscope Investigative Otolaryngology.2021; 6(1): 155. CrossRef
Thermal Treatment Options for Benign Thyroid Nodules—The Role of Radio-Frequency Ablation and Laser Therapy
Erivelto Volpi
Clinical Thyroidology.2021; 33(1): 17. CrossRef
Comparative efficacy of different ultrasound-guided ablation for the treatment of benign thyroid nodules: Systematic review and network meta-analysis of randomized controlled trials
Linye He, Wanjun Zhao, Zijing Xia, Anping Su, Zhihui Li, Jingqiang Zhu, Ivan D. Florez
PLOS ONE.2021; 16(1): e0243864. CrossRef
Unresolved Clinical Issues in Thermal Ablation of Benign Thyroid Nodules: Regrowth at Long-Term Follow-Up
Jung Suk Sim, Jung Hwan Baek
Korean Journal of Radiology.2021; 22(8): 1436. CrossRef
Current Status and Challenges of US-Guided Radiofrequency Ablation of Thyroid Nodules in the Long Term: A Systematic Review
Stella Bernardi, Andrea Palermo, Rosario Francesco Grasso, Bruno Fabris, Fulvio Stacul, Roberto Cesareo
Cancers.2021; 13(11): 2746. CrossRef
Update of Radiofrequency Ablation for Treating Benign and Malignant Thyroid Nodules. The Future Is Now
Ralph P. Tufano, Pia Pace-Asciak, Jonathon O. Russell, Carlos Suárez, Gregory W. Randolph, Fernando López, Ashok R. Shaha, Antti Mäkitie, Juan P. Rodrigo, Luiz Paulo Kowalski, Mark Zafereo, Peter Angelos, Alfio Ferlito
Frontiers in Endocrinology.2021;[Epub] CrossRef
Factors Associated with the Efficacy of Radiofrequency Ablation in the Treatment of Benign Thyroid Nodules
Huynh Q Khanh, Nguyen L Vuong, Tran Q Tien
World Journal of Endocrine Surgery.2021; 12(3): 117. CrossRef
Long-Term Outcomes of Thermal Ablation for Benign Thyroid Nodules: The Issue of Regrowth
Jung Suk Sim, Jung Hwan Baek, Rosaria Meccariello
International Journal of Endocrinology.2021; 2021: 1. CrossRef
Matrix 3D ultrasound-assisted thyroid nodule volume estimation and radiofrequency ablation: a phantom study
T. Boers, S. J. Braak, M. Versluis, S. Manohar
European Radiology Experimental.2021;[Epub] CrossRef
Learning curve analysis of radiofrequency ablation for benign thyroid nodules
Chi-Yu Kuo, Chien-Liang Liu, Chung-Hsin Tsai, Shih-Ping Cheng
International Journal of Hyperthermia.2021; 38(1): 1536. CrossRef

Clinical Study
Does Radiofrequency Ablation Induce Neoplastic Changes in Benign Thyroid Nodules: A Preliminary Study: Su Min Ha, Jun Young Shin, Jung Hwan Baek, Dong Eun Song, Sae Rom Chung, Young Jun Choi, Jeong Hyun Lee; Endocrinol Metab. 2019;34(2):169-178. Published online May 15, 2019; DOI: https://doi.org/10.3803/EnM.2019.34.2.169

5,647 View
81 Download
20 Web of Science
19 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background

To evaluate the clinical feasibility of radiofrequency ablation (RFA) of benign thyroid nodules along with cytomorphological alteration, and any malignant transformation through biopsy.

Methods

The data were retrospectively collected between April 2008 and June 2013 and core needle biopsy (CNB) was performed on 16 benign thyroid nodules previously treated using RFA. The parameters of the patients were compared, between the time of enrollment and the last follow-up examination, using linear mixed model statistical analysis.

Results

No atypical cells or neoplastic transformation were detected in the undertreated peripheral portion of treated benign nodules on the CNB specimen. RFA altered neither the thyroid capsule nor the thyroid tissue adjacent to the treated area. On histopathological examinations, we observed 81.2% acellular hyalinization, which was the most common finding. After a mean follow-up period of over 5 years, the mean volume of thyroid nodule had decreased to 6.4±4.2 mL, with a reduction rate of 81.3%±5.8% (P<0.0001).

Conclusion

RFA is a technically feasible treatment method for benign thyroid nodules, with no carcinogenic effect or tissue damage of the normal thyroid tissue adjacent to the RFA-treated zone.

Citations

Citations to this article as recorded by

Comparison of the Therapeutic Efficacy and Technical Outcomes between Conventional Fixed Electrodes and Adjustable Electrodes in the Radiofrequency Ablation of Benign Thyroid Nodules
Jae Ho Shin, Minkook Seo, Min Kyoung Lee, So Lyung Jung
Korean Journal of Radiology.2024; 25(2): 199. CrossRef
Thermoablation of thyroid nodules reveals excellent results with low morbidity
Robert M. Eisele, Philipp R. Scherber, Monika Schlüter, Thorsten Drews, Matthias Glanemann, Gereon Gäbelein
Technology and Health Care.2022; 30(3): 683. CrossRef
Radiofrequency ablation and related ultrasound‐guided ablation technologies for treatment of benign and malignant thyroid disease: An international multidisciplinary consensus statement of the American Head and Neck Society Endocrine Surgery Section with
Lisa A. Orloff, Julia E. Noel, Brendan C. Stack, Marika D. Russell, Peter Angelos, Jung Hwan Baek, Kevin T. Brumund, Feng‐Yu Chiang, Mary Beth Cunnane, Louise Davies, Andrea Frasoldati, Anne Y. Feng, Laszlo Hegedüs, Ayaka J. Iwata, Emad Kandil, Jennifer K
Head & Neck.2022; 44(3): 633. CrossRef
Thyroid Nodule Radiofrequency Ablation: Complications and Clinical Follow Up
James Y. Lim, Jennifer H. Kuo
Techniques in Vascular and Interventional Radiology.2022; 25(2): 100824. CrossRef
American Association of Clinical Endocrinology Disease State Clinical Review: The Clinical Utility of Minimally Invasive Interventional Procedures in the Management of Benign and Malignant Thyroid Lesions
Sina Jasim, Kepal N. Patel, Gregory Randolph, Stephanie Adams, Roberto Cesareo, Edward Condon, Tara Henrichsen, Malak Itani, Maria Papaleontiou, Leonardo Rangel, John Schmitz, Marius N. Stan
Endocrine Practice.2022; 28(4): 433. CrossRef
Efficacy of radiofrequency and laser thermal ablation in solving thyroid nodule-related symptoms and cosmetic concerns. A systematic review and meta-analysis
Roberto Cesareo, Silvia Egiddi, Anda M. Naciu, Gaia Tabacco, Andrea Leoncini, Nicola Napoli, Andrea Palermo, Pierpaolo Trimboli
Reviews in Endocrine and Metabolic Disorders.2022; 23(5): 1051. CrossRef
Comparison of ultrasound-guided radiofrequency ablation versus thyroid lobectomy for T1bN0M0 papillary thyroid carcinoma
Lin Yan, Xinyang Li, Yingying Li, Jing Xiao, Mingbo Zhang, Yukun Luo
European Radiology.2022; 33(1): 730. CrossRef
A systematic review and meta-analysis comparing tumor progression and complications between radiofrequency ablation and thyroidectomy for papillary thyroid carcinoma
Yuan-dong Sun, Hao Zhang, Hai-tao Zhu, Chun-xue Wu, Miao-ling Chen, Jian-jun Han
Frontiers in Oncology.2022;[Epub] CrossRef
RFA and benign thyroid nodules: Review of the current literature
Haris Muhammad, Prasanna Santhanam, Jonathon O. Russell, Jennifer H. Kuo
Laryngoscope Investigative Otolaryngology.2021; 6(1): 155. CrossRef
Radiofrequency ablation and thyroid nodules: updated systematic review
Haris Muhammad, Prasanna Santhanam, Jonathon O. Russell
Endocrine.2021; 72(3): 619. CrossRef
Complications of RFA for Thyroid Nodules: Prevention and Management
Rahul K. Sharma, Jennifer H Kuo
Current Otorhinolaryngology Reports.2021; 9(1): 79. CrossRef
Long-Term Results of Ultrasound-Guided Radiofrequency Ablation of Benign Thyroid Nodules: State of the Art and Future Perspectives—A Systematic Review
Hervé Monpeyssen, Ahmad Alamri, Adrien Ben Hamou
Frontiers in Endocrinology.2021;[Epub] CrossRef
Long-Term Outcomes of Thermal Ablation for Benign Thyroid Nodules: The Issue of Regrowth
Jung Suk Sim, Jung Hwan Baek, Rosaria Meccariello
International Journal of Endocrinology.2021; 2021: 1. CrossRef
Ultrasound-Guided Radiofrequency Ablation Versus Thyroid Lobectomy for Low-Risk Papillary Thyroid Microcarcinoma: A Propensity-Matched Cohort Study of 884 Patients
Lin Yan, Mingbo Zhang, Qing Song, Yukun Luo
Thyroid.2021; 31(11): 1662. CrossRef
Clinical Effects of Microwave Ablation in the Treatment of Low-Risk Papillary Thyroid Microcarcinomas and Related Histopathological Changes
Chenya Lu, Xingjia Li, Xiaoqiu Chu, Ruiping Li, Jie Li, Jianhua Wang, Yalin Wang, Yang Xu, Guofang Chen, Shuhang Xu, Chao Liu
Frontiers in Endocrinology.2021;[Epub] CrossRef
Ultrasound-Guided Thermal Ablation of Thyroid Nodules: Technicalities Progress and Clinical Applications, Especially in Malignant Thyroid Nodules
Enock Adjei Agyekum, Jian-hua Fu, Fei-Ju Xu, Yong-Zhen Ren, Debora Akortia, Qing Chen, Xiao-Qin Qian, Yuguo Wang, Xian Wang
Frontiers in Oncology.2021;[Epub] CrossRef
Comparison Between Radiofrequency Ablation and Microwave Ablation in the Treatment for Benign Thyroid Nodules: a Meta-analysis
Jing Wu, Junguo Liu, Li Liu
Indian Journal of Surgery.2021;[Epub] CrossRef
2020 European Thyroid Association Clinical Practice Guideline for the Use of Image-Guided Ablation in Benign Thyroid Nodules
Enrico Papini, Hervé Monpeyssen, Andrea Frasoldati, Laszlo Hegedüs
European Thyroid Journal.2020; 9(4): 172. CrossRef
Response: Long-Term Outcomes Following Thermal Ablation of Benign Thyroid Nodules as an Alternative to Surgery: The Importance of Controlling Regrowth (Endocrinol Metab 2019;34:117–23, Jung Suk Sim et al.)
Jung Suk Sim, Jung Hwan Baek
Endocrinology and Metabolism.2019; 34(3): 325. CrossRef

Thyroid
A Comparison of Ultrasound-Guided Fine Needle Aspiration versus Core Needle Biopsy for Thyroid Nodules: Pain, Tolerability, and Complications: Eun Ji Jeong, Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Jae Kyun Kim, Jeong Hyun Lee; Endocrinol Metab. 2018;33(1):114-120. Published online March 21, 2018; DOI: https://doi.org/10.3803/EnM.2018.33.1.114

5,385 View
61 Download
24 Web of Science
22 Crossref

Abstract PDF PubReader ePub

Background

To compare pain, tolerability, and complications associated with fine needle aspiration (FNA) versus core needle biopsy (CNB).

Methods

FNAs were performed using 23-gauge needles and CNBs were performed using 18-gauge double-action spring-activated needles in 100 patients for each procedure. Patients were asked to record a pain score using a 10-cm visual analog scale and procedure tolerability. Complications and number of biopsies were recorded.

Results

The median pain scores were similar for the FNA and CNB approaches during and 20 minutes after the biopsy procedures (3.7 vs. 3.6, P=0.454; 0.9 vs. 1.1, P=0.296, respectively). The procedure was tolerable in all 100 FNA patients and in 97 CNB patients (P=0.246). The mean number of biopsies was fewer in the CNB group (1.4 vs. 1.2, P=0.002). By subgroup analysis (staff vs. non-staff), no significant difference was detected in any parameter. There were no major complications in either group, but three patients who underwent CNB had minor complications (P=0.246).

Conclusion

FNA and CNB show no significant differences for diagnosing thyroid nodules in terms of pain, tolerability, or complications.

Citations

Citations to this article as recorded by

A comparative analysis of core needle biopsy and repeat fine needle aspiration in patients with inconclusive initial cytology of thyroid nodules
Xuejiao Su, Can Yue, Wanting Yang, Buyun Ma
Frontiers in Endocrinology.2024;[Epub] CrossRef
Assessing Adequacy: A Meta-Analysis of Rapid Onsite Evaluation of Thyroid Nodules
Peter P. Issa, Christina McCarthy, Mohammad Hussein, Aaron L. Albuck, Essam Emad, Mohamed Shama, Krzysztof Moroz, Eman Toraih, Emad Kandil
Journal of Surgical Research.2024; 296: 523. CrossRef
Histology-based and cytology-based needle sampling for targeted next-generation sequencing in the indeterminate thyroid tumors
Chun-Nan Chen, Tsung-Lin Yang
European Archives of Oto-Rhino-Laryngology.2023; 280(8): 3773. CrossRef
Preoperative evaluation of thyroid nodules – Diagnosis and management strategies
Tapoi Dana Antonia, Lambrescu Ioana Maria, Gheorghisan-Galateanu Ancuta-Augustina
Pathology - Research and Practice.2023; 246: 154516. CrossRef
Keloid Development After Fine Needle Aspiration of the Thyroid: A Rare Case and Review of Management Strategies
Shaniah S Holder, Alaerebo S Malvan-iyalla, Sara Arfan, Vimal Basani, Frederick Tiesenga
Cureus.2023;[Epub] CrossRef
Utilidad de la biopsia con aguja gruesa ecoguiada en nódulos tiroideos con punción aspirativa con aguja fina no diagnóstica
R. Cortázar-García, M.D. Martín-Escalante, L. Robles-Cabeza, C. Martínez-Santos
Radiología.2022; 64(3): 195. CrossRef
Thyroid diagnostic modalities (fine needle aspiration and core needle biopsy) with histology correlation: a tertiary centre experience
Sona J Appukutty, Anna Paterson, Nishant S Patel, Adam Duckworth, James Chan, Maria O'Donovan, Alison J Marker
Journal of Clinical Pathology.2022; 75(9): 620. CrossRef
Diagnostic performance of core needle biopsy for nodal recurrences in patients with head and neck squamous cell carcinoma
Ta-Hsuan Lo, Cheng-Ping Wang, Chun-Nan Chen, Tsung-Lin Yang, Pei-Jen Lou, Jenq-Yuh Ko, Yih-Leong Chang, Tseng-Cheng Chen
Scientific Reports.2022;[Epub] CrossRef
The efficacy of incorporating ultrasound-guided core biopsy into the clinical workflow of indeterminate thyroid tumors
Chun-Nan Chen, Min-Shu Hsieh, Yi-Hsuan Lee, Tsung-Lin Yang
Journal of the Formosan Medical Association.2022; 121(10): 2012. CrossRef
A Literature Review of Factors Associated With Pain From Fine Needle Aspiration Biopsy of Thyroid Nodules
Tao Liu, Manisha Tilak, Sara Awad, Joshua Lakoff
Endocrine Practice.2022; 28(6): 628. CrossRef
Usefulness of ultrasound-guided core biopsy in thyroid nodules with inconclusive fine-needle aspiration biopsy findings
R. Cortázar-García, M.D. Martín-Escalante, L. Robles-Cabeza, C. Martínez-Santos
Radiología (English Edition).2022; 64(3): 195. CrossRef
Permanent vocal fold paralysis after ultrasound-guided core needle biopsy of thyroid nodule
Kathrin Zimmerman, Matthew Hoffman, Amalee Smith, C. Blake Simpson
Otolaryngology Case Reports.2022; 24: 100455. CrossRef
Interobserver variability in ultrasound assessment of thyroid nodules
Jaber Alyami, Fahad F. Almutairi, Sultan Aldoassary, Amani Albeshry, Ali Almontashri, Mazen Abounassif, Majed Alamri
Medicine.2022; 101(41): e31106. CrossRef
Usage and Diagnostic Yield of Fine-Needle Aspiration Cytology and Core Needle Biopsy in Thyroid Nodules: A Systematic Review and Meta-Analysis of Literature Published by Korean Authors
Soon-Hyun Ahn
Clinical and Experimental Otorhinolaryngology.2021; 14(1): 116. CrossRef
Hydrodissection: A Novel Approach for Safe Core Needle Biopsy of Small High-Risk Subcapsular Thyroid Nodules
Hojat Ebrahiminik, Hossein Chegeni, Javad Jalili, Rambod Salouti, Hadi Rokni, Afshin Mohammadi, Ali Mosaddegh Khah, Seyed Mohammad Tavangar, Zahra Ebrahiminik
CardioVascular and Interventional Radiology.2021; 44(10): 1651. CrossRef
A Blinded Randomized Trial Comparing 2 Needle Gauges for Fine‐Needle Biopsy of Thyroid Nodules
Christopher M. Shumrick, Jonathan C. Simmonds, Lorna L. Ogden, Cindi A. Snowden, Jagdish K. Dhingra
OTO Open.2021;[Epub] CrossRef
Application of biomarkers in the diagnosis of uncertain samples of core needle biopsy of thyroid nodules
Yan Xiong, Xin Li, Li Liang, Dong Li, Limin Yan, Xueying Li, Jiting Di, Ting Li
Virchows Archiv.2021; 479(5): 961. CrossRef
Diagnostic Efficacy and Safety of Core Needle Biopsy as a First-Line Diagnostic Method for Thyroid Nodules: A Prospective Cohort Study
Min Ji Hong, Dong Gyu Na, Hunkyung Lee
Thyroid.2020; 30(8): 1141. CrossRef
Comparison Between Fine Needle Aspiration and Core Needle Biopsy for the Diagnosis of Thyroid Nodules: Effective Indications According to US Findings
Soo Yeon Hahn, Jung Hee Shin, Young Lyun Oh, Ko Woon Park, Yaeji Lim
Scientific Reports.2020;[Epub] CrossRef
2019 Practice guidelines for thyroid core needle biopsy: a report of the Clinical Practice Guidelines Development Committee of the Korean Thyroid Association
Chan Kwon Jung, Jung Hwan Baek, Dong Gyu Na, Young Lyun Oh, Ka Hee Yi, Ho-Cheol Kang
Journal of Pathology and Translational Medicine.2020; 54(1): 64. CrossRef
Pathological diagnosis of thyroid nodules based on core needle biopsies: comparative study between core needle biopsies and resected specimens in 578 cases
Yan Xiong, Limin Yan, Lin Nong, Yalin Zheng, Ting Li
Diagnostic Pathology.2019;[Epub] CrossRef
The Significance of Having an Excellent Patient's Comfort with Thyroid Core Needle Biopsy
Pierpaolo Trimboli, Luca Giovanella
Endocrinology and Metabolism.2018; 33(1): 53. CrossRef

First
Prev
Page of 1
Next
Last

Search